Metabolics is a best in world specialist protocol for rebooting the metabolic system and redefining the fat burning pathways.
PHASE 1: THE MORNING IGNITION
The chemical “first light” designed to wake the mitochondria and set the day’s burn rate.
Morning Ignition is the Wake-Up Call for your DNA. While the world is stumbling toward the coffee pot, you are already upgrading your cellular power grid. You aren’t just starting your day; you are launching a metabolic offensive.
Liothyronine Sodium
The pure sodium salt of the T3 thyroid hormone. Metabolic & Fat Burn: This is the master throttle of the human body. It increases the basal metabolic rate (BMR) by stimulating oxygen and energy consumption in almost all tissues. It forces the liberation of free fatty acids from storage. Balance & Fertility: In both genders, T3 is required for reproductive health. We avoid excessive levels that could disrupt the cycle by layering in to METABOLIC BOOST cycling it in and out of the protocol as needed. For men, it supports the metabolic heat needed for healthy spermatogenesis. Longevity: As we age, the conversion of T4 to T3 often slows. Proper T3 levels prevent metabolic hibernation, keeping the brain sharp and the body composition lean in post-menopausal women and ageing men.
3,5-Diiodotyrosine (T2)
Found in Kelp & Seaweeds. A precursor/metabolite in the thyroid cascade. Metabolic & Fat Burn: A more localized metabolic stimulator. It specifically targets the mitochondria in brown adipose tissue (BAT), increasing thermogenesis without the heavy systemic strain of T3. Balance & Fertility: It provides a gentle metabolic signal that supports hormonal balance without significant risk of suppression. Longevity: Excellent for later life when the central nervous system becomes more sensitive to stimulants; it maintains metabolic vigor.
SR-9011 & SR-9009
Synthetic Rev-ErbA agonists (Circadian Rhythm modulators). Metabolic & Fat Burn: These reset the cellular clock, tricking the body into thinking it is constantly in a state of high-energy daytime activity. This increases fat oxidation in the muscles and suppresses fat storage in the liver. Balance & Fertility: By aligning circadian rhythms, they support the pulsatile release of reproductive hormones (LH/FSH). Longevity: They fight ‘inflammaging” and muscle sarcopenia, making them vital for maintaining an active physical profile in the 60s and beyond.
NAD+ / NADH / NADPH
Present in all living cells; derived from Vitamin B3 (Niacin). Metabolic & Fat Burn: The raw electron currency. Without these, the mitochondria cannot turn fat into ATP (energy). They are the essential spark plugs for the metabolic engine. Balance & Fertility: NAD+ is critical for egg quality in women and sperm motility in men. It repairs DNA damage within the reproductive line. Longevity & Later Life: This is the gold standard for longevity. It fuels the Sirtuin enzymes that repair DNA and prevent the cellular decay”associated with ageing and menopause.
Pyrroloquinoline Quinone (PQQ)
Found in fermented soy (natto), green peppers, and parsley. Metabolic & Fat Burn: It stimulates mitochondrial biogenesis—literally growing new power plants within your cells to burn more fuel. Balance & Fertility: Protects the reproductive organs from oxidative stress. Longevity: A potent neuroprotector. It helps maintain cognitive speed and prevents the metabolic slow-down caused by a shrinking mitochondrial pool.
Prasterone & Pregnenolone (Base Versions)
Produced naturally in the adrenal glands from cholesterol. Metabolic & Fat Burn: These provide the hormonal substrate. They ensure that while you are burning fat, your body doesn’t feel depleted, maintaining the drive to stay active. Balance & Fertility: The fundamental building blocks for estrogen and testosterone. They ensure the reproductive system has ample raw material to function. Longevity: These are the anti-involution hormones. They prevent the drying of tissues and the loss of bone density in post-menopausal women and ageing men.
Huperzine A
Extracted from the Fir Clubmoss (Huperzia serrata). Metabolic & Fat Burn: Enhances the mind-muscle connection and increases Growth Hormone (GH) signalling by inhibiting the brake enzyme, acetylcholinesterase. Balance & Fertility: Generally neutral, though by reducing stress and improving focus, it supports the parasympathetic state needed for arousal. Longevity: A premier tool for preventing age-related memory loss and maintaining the neurological wiring of the metabolism.
Levocarnitine Tartrate
Found in red meat and synthesised from lysine. Metabolic & Fat Burn: The shuttle. It physically carries long-chain fatty acids into the mitochondria to be burned. Without it, fat just sits in the bloodstream. Balance & Fertility: Significantly improves sperm morphology and motility in men; supports healthy ovulation in women. Longevity: Protects the ageing heart and brain from lipid buildup and supports energy levels in those with naturally declining carnitine stores.
Vardenafil / Vardenafil Hydrochloride
Selective PDE5 Inhibitor (Hydrochloride is the more soluble salt). Metabolic & Fat Burn: It opens the pipes. By increasing blood flow (vasodilation), it ensures that your T3 and Levocarnitine actually reach the cold, stubborn fat deposits. Balance & Fertility: Widely known to support male erectile function; in women, it increases pelvic blood flow, which can enhance sensitivity and uterine health. Longevity & Later Life: Essential for cardiovascular flexibility. It prevents the hardening of arteries and supports healthy blood pressure as the vascular system ages.
PHASE 2: THE MID-DAY SHIELD
A strategic intervention to divert nutrients into lean tissue while protecting the metabolic engine from burnout.
The Mid-day shield is where the ‘magic’ happens. While your morning was about setting the fire, mid-day is about making sure that fire only burns the logs (fat) and doesn’t melt the fireplace (muscle). You’re telling your body: ‘Keep the muscle, lose the sugar, and turn up the heat.’
Capromorelin
A potent active growth hormone secretagogue (GHS). Metabolic & Fat Burn: It mimics the action of ghrelin to trigger a pulse of Growth Hormone (GH). This signals the body to preserve muscle tissue while simultaneously mobilising fat stores for energy, preventing the wasting often seen in high-speed weight loss. Balance & Fertility: In men, GH pulses support healthy testosterone production; in women, it aids in maintaining the integrity of the uterine lining and follicular development. Longevity: GH levels naturally crater as we age (somatopause). Capromorelin helps maintain bone density, skin elasticity, and muscular fullness well into the post-menopausal and late-life years.
Epicatechin / Dexepicatechin / Cianidanol
Found in dark chocolate (cacao), green tea, and grapes. Metabolic & Fat Burn: These act as Myostatin Inhibitors. By lowering the chemical brake on muscle growth, they allow for a more efficient metabolic furnace. A higher muscle-to-fat ratio ensures a higher resting metabolic rate. Balance & Fertility: Highly antioxidant; they protect reproductive cells from the oxidative stress that can lead to infertility. Longevity: These are essential for fighting sarcopenia (age-related muscle loss). In later life, maintaining muscle is the single greatest predictor of metabolic health and mobility.
Berberine
Extracted from the roots and bark of shrubs like Barberry (Berberis). Metabolic & Fat Burn: Often called ‘Exercise in a bottle,’ it activates the AMPK pathway. This forces the body to stop storing fat and start burning it, while significantly improving how your cells respond to insulin. Balance & Fertility: For women, it is a gold standard for balancing androgen levels and supporting ovulatory regularity. For men, it reduces the systemic inflammation that can impair hormone production. Longevity: It mimics the life-extending effects of caloric restriction, protecting against the metabolic syndrome and blood sugar swings common in post-menopausal years.
Telmisartan / Telmisartan Sodium
An Angiotensin II Receptor Blocker (ARB) with unique PPAR-gamma and PPAR-delta activity. Metabolic & Fat Burn: Beyond its role in managing blood pressure, it activates the same genetic pathways as high-intensity cardio. It tells the body to switch from burning glucose to burning fatty acids as its primary fuel source. It’s powerful and cycled in and out of the protocol as METABOLIC BOOST. Balance & Fertility: Protects the delicate vascular beds of the reproductive organs, ensuring optimal nutrient delivery for fertility. Longevity: A premier longevity agent. It protects the kidneys, heart, and brain from age-related decline and arterial stiffness in both genders.
Phlorizin
Derived from the bark of apple trees. Metabolic & Fat Burn: It inhibits the SGLT1 and SGLT2 transporters, meaning it helps block the reabsorption of glucose in the kidneys and the absorption of sugar in the gut. This effectively flushes excess sugar out of the system. Balance & Fertility: By preventing insulin spikes, it keeps the hormonal environment quiet and receptive, which is vital for balanced reproductive cycles. Longevity: Sugar is the primary driver of “glycation” (cellular ageing). Phlorizin helps keep this at bay, preserving tissue youthfulness in older age.
Thioctic Acid (Tromethamine) / Lipoic Acid / Dihydrolipoic Acid
Synthesised in the mitochondria; found in spinach and organ meats. Metabolic & Fat Burn: Known as the Universal Antioxidant. These agents act as essential co-factors for the enzymes that turn nutrients into energy. They are incredible glucose disposal agents, ensuring carbs fuel your muscles rather than your fat cells. Balance & Fertility: They recycle other antioxidants like Vitamin C and E, protecting the ovaries and testes from environmental toxins. Longevity: Crucial for preventing diabetic complications and peripheral neuropathy. They keep the metabolic fire clean and efficient in later life.
Palmitic Acid & Terpineol
Palmitic acid is the most common saturated fatty acid (found in palm oil/dairy); Terpineol is found in pine trees and lilacs. Metabolic & Fat Burn: These act as structural signaling molecules. They help stabilize the cell membranes during the high-speed metabolic turnover induced by T3 and SR-9011. Balance & Fertility: Healthy fats are the precursor to all sex hormones; they ensure the lubrication and structural integrity of the reproductive system. Longevity: Essential for skin barrier health and cellular communication, which often break down during the hormonal shifts of menopause and andropause.
Fucoxanthin
A carotenoid found in brown seaweed and wakame. Metabolic & Fat Burn: It targets White Adipose Tissue (the stubborn kind) and stimulates the expression of UCP1. This uncouples energy production, essentially turning your fat cells into small heaters that burn calories as pure heat. Balance & Fertility: Supports healthy lipid profiles, which is a prerequisite for a balanced endocrine system. Longevity & Later Life: Specifically effective at reducing visceral belly fat, which is the most dangerous inflammatory tissue in post-menopausal women and ageing men.
PHASE 3: THE AFTERNOON DYNAMICS
Targeting the stubborn”locks and maintaining hormonal equilibrium as the day’s metabolic stress peaks.
Afternoon Dynamics is the Biological Master-Key. While the morning was a metabolic blitz, the afternoon calms the nervous system and is a sophisticated heist. You are deploying Rauwolfia to pick the locks on your most stubborn, deep-seated fat deposits while Acolbifene stands guard like a high-level security guard for your fertility. You aren’t just burning calories anymore; you are strategically dismantling the Emergency Storage without ever letting the hormonal alarm bells go off. It’s pure, calculated metabolic finesse.
Acolbifene
A high-affinity Selective Estrogen Receptor Modulator (SERM). Metabolic & Fat Burn: By blocking estrogen receptors in adipose tissue, it prevents the estrogen-driven fat storage typically found in the lower body and midsection. It acts as the metabolic Traffic Cop, ensuring hormones don’t signal for storage. Balance & Fertility: This is the cornerstone of the fertility shield. In men, it prevents the brain from sensing too much estrogen, which forces the natural production of LH and FSH (testosterone and sperm). In women, it helps maintain a healthy estrogen-to-progesterone balance. Longevity: Protects bone density and breast/uterine tissue health. For post-menopausal women, it offers a sophisticated way to manage estrogenic signaling without the risks of traditional HRT.
Ajmaline / Deserpidine / Rescinnamine
Rauwolfia Serpentina Root, The Indian Snakeroot plant. Metabolic & Fat Burn: These contain powerful alkaloids that act as Alpha-2 Adrenergic Antagonists. This is the Key to stubborn fat; it unlocks the receptors that usually prevent fat cells from releasing their contents in areas like the hips and lower back. Balance & Fertility: By lowering systemic stress and sympathetic overdrive, they help the body stay in the Rest and Digest state necessary for reproductive health. Longevity & Later Life: Traditionally used to manage blood pressure and nervous tension. In later life, they provide a calm, steady vascular environment and protect the heart from over-firing.
Phosphatidyl Serine
Found in high concentrations in fish, soy lecithin, and sunflower seeds. Metabolic & Fat Burn: The master Cortisol Blunt. It tells the adrenal glands to stop overproducing stress hormones. High cortisol is the primary enemy of fat loss, as it forces the body to hold onto belly fat and break down muscle. Balance & Fertility: Lowering cortisol is the fastest way to restore a suppressed libido and improve egg/sperm quality, as stress is a primary driver of reproductive shutdown. Longevity & Later Life: A premier brain nutrient. It helps maintain the fluidity of cell membranes in the brain, fighting off age-related cognitive decline and improving memory.
Honokiol
Extracted from the bark of the Magnolia tree (Magnolia officinalis). Metabolic & Fat Burn: It acts as a natural anxiolytic that doesn’t slow down the metabolism. It balances the intensity that can come from T3 and SR-9011, preventing metabolic burnout and ensuring you don’t stress-eat. Balance & Fertility: It supports the GABA system, which is essential for the deep relaxation required for hormonal pulsing and healthy sleep cycles. Longevity: Shows incredible promise in protecting the brain from neuro-inflammation and supporting cellular health in the later decades.
Resveratrol & Pterostilbene
Resveratrol is famously found in red wine/grapes; Pterostilbene is its more potent cousin found in blueberries. Metabolic & Fat Burn: These are Sirtuin Activators. They mimic the metabolic benefits of fasting and exercise, telling your genes to prioritize fat burning and DNA repair over growth and storage. Balance & Fertility: They protect the ovarian reserve in women and support healthy testosterone levels in men by reducing oxidative damage to the endocrine glands. Longevity: These are the pillars of the anti-aging world and support heart health in the post-menopausal and andropause years.
Syringate (Syringic Acid)
Found in honey, acai palm, and various traditional herbs. Metabolic & Fat Burn: It possesses powerful anti-hyperglycemic properties. It helps stabilize blood sugar as the day winds down, preventing late-day energy crashes and cravings. Balance & Fertility: Its anti-inflammatory nature ensures that the reproductive tract remains free from the low-grade inflammation that often interferes with conception. Longevity: Provides systemic protection for the liver and kidneys, which can become overworked in later life due to years of processing nutrients and medications.
PHASE 4: THE NIGHTLY RECOVERY
The “Clean-Up Crew” designed to seal energy leaks, neutralize metabolic soot, and recharge the cellular battery.
Nightly recovery is the Biological Janitor. While you’re dreaming, Apigenin is locking the doors to keep your energy in, Ubiquinol is scrubbing the mitochondrial floors, and the Minerals are refilling the tanks. You aren’t just sleeping; you’re undergoing a nightly Body Reset so you can wake up tomorrow and do it all again, only leaner.
Apigenin
A flavonoid found in abundance in parsley, celery, and chamomile. Metabolic & Fat Burn: This is the Plug. It inhibits the CD38 enzyme, which is the primary NAD+ sink in the body. By stopping CD38, Apigenin ensures your morning NAD+ dose stays in your cells rather than being wasted. Balance & Fertility: It is a gentle aromatase inhibitor, helping to keep estrogen in a healthy range for both men and women, which is vital for libido and mood. Longevity: A legendary sleep aid and anti-inflammatory. In later life, it protects the brain and prostate (in men) while supporting the deep, restorative sleep that becomes harder to achieve after menopause.
Ubiquinol
The reduced, active form of CoQ10, found in heart and liver meats. Metabolic & Fat Burn: The mitochondrial Exhaust Fan. When your metabolism is running hot (thanks to T3), it creates oxidative smoke. Ubiquinol clears this smoke, preventing cellular damage and keeping the engine from stalling. Balance & Fertility: One of the most studied nutrients for improving egg quality and sperm motility. It provides the literal energy needed for the spark of life. Longevity: Critical for heart health and gum health. As natural CoQ10 production drops after age 40, Ubiquinol supplementation is essential to prevent the fatigue associated with ageing.
Prasterone (Sulfate/Enantate) & Pregnenolone Acetate
The esterified, long-acting versions of DHEA and Pregnenolone. Metabolic & Fat Burn: These provide a slow-release drip of hormonal support throughout the night. They ensure the body stays in a repair (anabolic) state rather than a stress (catabolic) state during sleep. Balance & Fertility: By providing a steady baseline of pro-hormones, they ensure the body never feels the panic of low hormone levels, which keeps the fertility axis stable. Longevity: These are the Sleep Protectors. They help maintain skin thickness and vaginal/mucosal health in post-menopausal women and support overnight muscle repair in men.
Magnesium Glycinate
Mineral found in seeds, nuts, and leafy greens, chelated with the amino acid Glycine. Metabolic & Fat Burn: Magnesium is a co-factor in over 300 enzymatic reactions, including those that break down fat. The Glycine attachment helps lower core body temperature, which is the signal for the body to enter deep sleep. Balance & Fertility: Vital for the production of testosterone and the regulation of the menstrual cycle. It prevents the cramping and tension that can disrupt reproductive comfort. Longevity: The ultimate Mineral Guard. It protects against arterial calcification, supports bone density, and prevents the neurological hyperexcitability often seen in the elderly.
Potassium (Gluconate & Citrate)
Abundant in bananas, avocados, and coconut water. Metabolic & Fat Burn: It regulates the Sodium-Potassium Pump. When you use T3 and SR-9011, your cells pump fluids and ions at a fast rate. Potassium ensures your cells don’t deflate, keeping your muscles looking full and your heart rhythm steady. Balance & Fertility: Maintains the electrical gradient required for cellular communication and hormone transport. Longevity: Essential for stroke prevention and maintaining healthy blood pressure as the kidneys become less efficient at handling salt in later years.
Aminobenzoic Acid (PABA) & 4 7 Dioxosebacic Acid
PABA is a non-protein amino acid found in grains and eggs; Dioxosebacic acid is a specialized dicarboxylic acid. Metabolic & Fat Burn: These act as Tissue Refiners. They support the structural integrity of the skin and connective tissues, ensuring that as you lose fat, your skin snaps back rather than becoming saggy. Balance & Fertility: PABA is often used to support the health of the intestinal flora, which is the second brain for hormone metabolism. Longevity: PABA is famous for its Anti-Gray properties for hair and its ability to protect the skin from UV damage, making it a staple for maintaining a youthful appearance into and after the 70s.
Quick Look:
To manage all 50+ isolates without overwhelming your receptors the METABOLIC protocol is deployed throughout the day to target the precise physiological window where it is most needed.
🌅 PHASE 1: THE MORNING IGNITION (Metabolic Start)
Maximizes the “Clock” and “Thyroid” signals.
- The Thyroid Engine: 3 5 Diiodotyrosine, Liothyronine Sodium
- The Circadian Command: SR-9011, SR-9009.
- The Energy Battery: NAD+, NADH, NADPH, Pyrroloquinoline Quinone (PQQ).
- The Hormone Base: Prasterone, Pregnenolone, 16 Bromoepiandrosterone.
- The Cognitive Spark: Huperzine A.
- The Transport: Levocarnitine Tartrate.
- The Vascular Prep: Vardenafil, Vardenafil Hydrochloride.
Note: Liothyronine Sodium is only used in the METABOLIC BOOST protocol if the client needs extra thyroid support and then cycled through a maximum 8 week on an 4 week off window.
☀️ PHASE 2: THE MID-DAY SHIELD (Anabolic & Glucose)
Focus on muscle protection and carbohydrate management.
- The Growth Pulse: Capromorelin.
- The Muscle Armor: Epicatechin, Dexepicatechin, Cianidanol.
- The Glucose Shuttles: Berberine, Phlorizin, Telmisartan, Telmisartan Sodium.
- The Metabolic Acids: Lipoic Acid, Thiotic Acid Tromethamine, Dihydrolipoic Acid.
- The Structural Fatty Acids: Palmitic Acid, Terpineol.
- The Fat Pigment: Fucoxanthin.
Note: Telmisartan, & Telmisartan Sodium are part of the METABOLIC BOOST protocol and added in short cycles to support specific clients needs.
🌇 PHASE 3: THE AFTERNOON DYNAMICS (Stubborn Fat & Estrogen)
Targeting the alpha-receptors and hormonal balancing.
- The Rauwolfia Complex: Rauwolfia Serpentina Root, Ajmaline, Deserpidine, Rescinnamine.
- The Fertility Shield: Acolbifene.
- The Stress Buffer: Phosphatidyl Serine, Honokiol.
- The Sirtuin Activators: Resveratrol, Pterostilbene.
- The Syringic Acids: Syringate.
🌙 PHASE 4: THE NIGHTLY RECOVERY (Cellular Repair)
Sealing the “leaks” and calming the system for deep repair.
- The NAD+ Guard: Apigenin.
- The Mitochondrial Exhaust: Ubiquinol.
- The Long-Acting Hormones: Prasterone Sulfate, Prasterone Sodium Sulfate Anhydrous, Prasterone Enantate, Pregnenolone Acetate.
- The Electrolyte Balance: Magnesium Glycinate, Potassium Gluconate, Potassium Citrate.
- The Repair Agents: Aminobenzoic Acid, 4 7 Dioxosebacic Acid.